Friday, April 27, 2012

Vaccines


genome.fieldofscience.com



Vaccines are a controversial topic. Are they safe? Do they work? Do they actually cause disease? Setting these questions aside for a minute, I want to briefly discuss the anthrax vaccine. Yes, there is a vaccine! It is also made for both animals and humans. Personally, I don't hear about a lot of vaccines for bacteria - usually just viruses. There is only one vaccine that is licensed and approved called, BioThraxTM. Developed in 1970, it is made with attenuated B. anthracis and recommended for people 18-65 years old, who also happen to be at high risk of exposure to B. anthracis (fda.gov). It is suggested that the vaccine will protect against cutaneous and inhalation anthrax. Typically, one needs a series of 5 shots, plus annual boosters.
Check out the vaccine fact sheet from the CDC: http://www.cdc.gov/vaccines/pubs/vis/downloads/vis-anthrax.pdf

While trying to find some vaccine information, I stumbled upon this site, which actually seems more like a blog. http://genome.fieldofscience.com/2011/10/anthrax-vaccine-boondoggle.html Either way the writer, Steven Salzberg, is very opinionated about the anthrax vaccine. He acknowledges that vaccines are vital to today's world because they have eradicated diseases and saved lives. However, he insists that the anthrax vaccine is not a good idea. Polio and influenza, for example, are highly contagious and easily transmissible. Salzberg states clearly that anthrax is not infectious because it cannot spread from one person to another. I myself must admit that I have never heard of anthrax being spread person to person. Salzberg claims that making the vaccine is a complete waste of government money and scientist's time, especially because the Washington Post wrote an article about a clinical study where the vaccine would be tested in children. Rob Stein, the writer of the article states, "The National Biodefense Science Board (NBSB), which advises the federal government on issues related to bioterrorism, voted 12-1 to recommend that the Health and Human Services Department move forward with a study aimed at determining whether the vaccine is safe and effective in children and identifying the best dose." Personally, I will have to conduct a bit more research, as this sounds borderline unethical (experimenting to see if children will get anthrax if a dose isn't high enough). I see benefits of the vaccine for people at high risk such as farmers or people who work with hides and furs. I would not argue that a vaccine would be to military men and women's advantage. My hesitance lies in giving vaccines to people who are not at risk because it would be completely unnecessary. One of Darwin's four postulates says that there is variation in populations. There is also the topic of resistance that correlates with variation. One strain might be more resistant than another. B. anthracis could easily mutate and if several people receive a vaccine, the vaccine might not protect against the mutated organism. This new one would be selected for and the vaccine would be, quite frankly, worthless. At least, that's how I see it :/
A child recieving a vaccine. Hope she gets a sticker after!
nydailynews.com


The Washington Post article can be found here or linked in Salzberg's article.http://www.washingtonpost.com/national/health-science/federal-advisers-endorse-testing-anthrax-vaccine-in-children/2011/10/27/gIQA95i7PM_story.html

Other Sources:

Sunday, April 15, 2012

Storytime:

Athrax, the illness resulting from contact with Bacillus anthracis, has been an important disease throughout history. Throughout World War I and World War II, opposing sides would use anthrax as a biological weapon because of its capabilities to infect and survive as a spore. In WWI, German soldiers were sent to five countries, including the United States, to infect the animals with anthrax.  Throughout the 1930’s and 1940’s, different countries experimented with anthrax. During World War II, the Allies made biological weapons in the form of anthrax bombs. Following the war, scientist continued to research the potential of Bacillus anthracis and anthrax. President Richard Nixon decided that it was necessary that biological weapons only be researched for defensive purposes. However, many in other countries experimented with this potential weapon. In fact, the Soviet Union was suspected to have developed a strain that was resistant to antibiotics and a strain resistant to vaccines. Jumping to after the September 11 attacks on the US, anthrax spores were sent in the mail via four letters in the US Postal service. These spores took the form of a white powder. Five died and more suffered symptoms of anthrax.

U.S. Postal Service taking precautions
washingtonpost.com
Now for a personal story! One of the reasons I chose this organism as a topic was because of this event. I was in the 5th grade in 2001 when these events were occurring. I heard about anthrax and how it was in the mail, but never quite understood the surrounding issues. I knew that anthrax was a white powder and was very dangerous. I went to a small Catholic grade school where students brought lunch every day. My mom carefully picked out healthy foods for me and packed them in my “cool” denim lunchbox.  One day at lunch when I opened my lunchbox I saw everything was neatly packed in ziplock bags, as per usual. I ate with a group of my friends and talked about whatever fifth graders find interesting. When I got to my tomato (whole), I saw a something odd: a white powder. Convinced it was anthrax, I put the tomato back in my lunchbox to bring home to show my mom what happened at school.  I knew my mom wouldn’t try to hurt me, but was confused as to where the alleged anthrax came from. I washed it off my hands and was nervous the rest of the day because I heard from the news what anthrax can cause. After school when my mom later asked the typical mom question, “How was school today?” I told her about my anthrax encounter. She gave me a conflicted look that was between wanting to laugh and feeling bad for me because I was scared. My mom then told me that as she was multitasking that morning, making breakfast and lunches for us kids, she spilled baking soda on the kitchen counter. Some ended up in my lunchbox. Relieved, I rinsed off my tomato and ate it for an after school snack.

Anthrax powder
extremumspiritum.com
Baking Soda
moneysavingmom.com

Easy mistake right?!?!? Maybe? For a fifth grader?
Kelsey